Higher Education for Development (HED) organized an Africa-U.S. Higher Education Initiative Partners’ Meeting that was held at the United Nations Conference Centre in Addis Ababa, Ethiopia February 13-15, 2012 for the African and U.S. partnership directors and invited guests from various development agents. Addis Ababa University and the Ethiopian Ministry of Education assisted in hosting the meetings. Representatives from the Africa-U.S. Higher Education Initiative, Addis Ababa University, the American Council on Education, the Association of Public and Land-grant Universities (A•P•L•U), Higher Education for Development, the Association of African Universities, the World Bank, the African Union Commission, the U.S. Embassy in Ethiopia, Ethiopian Ministry of Education, USAID/Ethiopia, the African Capacity Building Foundation, the European Universities Association, the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM), the University of Cape Coast in Ghana, as well as 2009 World Food Prize Laureate Gebisa Ejeta and several partnership directors of other successful USAID- and HED-sponsored partnerships in Africa presented during the meetings. Also contributing at the meetings were representatives from the Association of American Universities, the American Association of State Colleges and Universities, and the National Association of Independent Colleges and Universities. A special focus of the meetings were the presentations by and discussions of each of the 11 Africa-U.S. Higher Education Initiative partnerships on their activities, outcomes, challenges and lessons learned to date.